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-Multiple myeloma must be included in the differential diagnosis of any lytic bone lesion, whether well-defined or ill-defined in age > 40.
-The most common location is in the axial skeleton (spine, skull, pelvis and ribs) and in the diaphysis of long bones (femur and humerus).
-Most common presentation: multiple lytic 'punched out' lesions.
-Multiple myeloma doe not show any uptake on bone scan.
-Discriminator: Must be over age 40.
http://www.radiologyassistant.nl/en/4bc6176e56228
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