Zone of transition
-In order to classify osteolytic lesions as well-defined or ill-defined, we need to look at the zone of transition between the lesion and the adjacent normal bone.
-The zone of transition is the most reliable indicator in determining whether an osteolytic lesion is benign or malignant .
-The zone of transition only applies to osteolytic lesions since sclerotic lesions usually have a narrow transition zone.
http://www.radiologyassistant.nl/en/494e15cbf0d8d
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